Version 5.4
Homo sapiens Protein: PCID2
Summary
InnateDB Protein IDBP-52454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCID2
Protein Name PCI domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364628
InnateDB Gene IDBG-52450 (PCID2)
Protein Structure
UniProt Annotation
Function Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0043488 regulation of mRNA stability
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048536 spleen development
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:2000117 negative regulation of cysteine-type endopeptidase activity
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR000717 Proteasome component (PCI) domain
IPR013143 PCI/PINT associated module
PFAM PF01399
PRINTS
PIRSF
SMART SM00088
SM00753
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5JVF3
PhosphoSite PhosphoSite-Q5JVF3
TrEMBL A0A024RDZ9
UniProt Splice Variant
Entrez Gene 55795
UniGene Hs.741363
RefSeq NP_060856
HUGO HGNC:25653
OMIM 613713
CCDS CCDS9532
HPRD 07749
IMGT
EMBL AF183426 AK000888 AK001185 AK001302 AK002167 AK023313 AK024478 AL136221 AL137002 BC016614 BC031246 CH471085
GenPept AAG09695 AAH16614 AAH31246 BAA91407 BAA91542 BAA91611 BAA92118 BAB14521 BAB15768 CAI13792 CAI13793 CAI13794 CAI41377 CAI41378 CAI41379 CAI41391 EAX09193 EAX09194 EAX09195 EAX09197 EAX09198 EAX09199

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca