InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2F1

Summary

InnateDB Protein

IDBP-52539.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2F1

Protein Name

cytochrome P450, family 2, subfamily F, polypeptide 1

Synonyms

C2F1; CYP2F;

Species

Homo sapiens

Ensembl Protein

ENSP00000333534

InnateDB Gene

IDBG-52537 (CYP2F1)

Protein Structure

UniProt Annotation

Function

May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. {ECO:0000269PubMed:1974816}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305PubMed:10383923}; Peripheral membrane protein {ECO:0000305PubMed:10383923}. Microsome membrane {ECO:0000269PubMed:10383923}; Peripheral membrane protein {ECO:0000269PubMed:10383923}.

Disease Associations

Tissue Specificity

Expressed in lung. Rarely detected in liver and placenta. {ECO:0000269PubMed:1974816, ECO:0000269PubMed:8619884}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0009636	response to toxic substance
GO:0018931	naphthalene metabolic process
GO:0018979	trichloroethylene metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR020469 Cytochrome P450, CYP2 family

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00465
PR01957

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P24903