InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLCB1

Summary

InnateDB Protein

IDBP-52545.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCB1

Protein Name

phospholipase C, beta 1 (phosphoinositide-specific)

Synonyms

EIEE12; PI-PLC; PLC-154; PLC-I; PLC154; PLCB1A; PLCB1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000367908

InnateDB Gene

IDBG-52543 (PLCB1)

Protein Structure

UniProt Annotation

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Subcellular Localization

Nucleus membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250}.

Disease Associations

Epileptic encephalopathy, early infantile, 12 (EIEE12) [MIM:613722]: A form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high- voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. {ECO:0000269PubMed:20833646}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	11 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008081	phosphoric diester hydrolase activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007215	glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007613	memory
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016042	lipid catabolic process
GO:0021987	cerebral cortex development
GO:0032735	positive regulation of interleukin-12 production
GO:0035556	intracellular signal transduction
GO:0035722	interleukin-12-mediated signaling pathway
GO:0035723	interleukin-15-mediated signaling pathway
GO:0040019	positive regulation of embryonic development
GO:0043547	positive regulation of GTPase activity
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0045663	positive regulation of myoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046330	positive regulation of JNK cascade
GO:0046488	phosphatidylinositol metabolic process
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0048639	positive regulation of developmental growth
GO:0060466	activation of meiosis involved in egg activation
GO:0070498	interleukin-1-mediated signaling pathway
GO:0080154	regulation of fertilization
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
GO:2000344	positive regulation of acrosome reaction
GO:2000438	negative regulation of monocyte extravasation
GO:2000560	positive regulation of CD24 biosynthetic process

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016607	nuclear speck
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR009535 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
IPR014815 PLC-beta, C-terminal
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00388
PF00387
PF06631
PF08703
PF09279

PRINTS

PR00360
PR00390

PIRSF

PIRSF000956

SMART

SM00239
SM00148
SM00149

TIGRFAMs

Post-translational Modifications

Modification

Cross-References