Version 5.4
Homo sapiens Protein: PARP9
Summary
InnateDB Protein IDBP-52596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARP9
Protein Name poly (ADP-ribose) polymerase family, member 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000353512
InnateDB Gene IDBG-52594 (PARP9)
Protein Structure
UniProt Annotation
Function In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes. {ECO:0000269PubMed:16809771, ECO:0000269PubMed:23230272}.
Subcellular Localization Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner.
Disease Associations Note=Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors.
Tissue Specificity Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells. {ECO:0000269PubMed:11110709, ECO:0000269PubMed:16809771}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006302 double-strand break repair
GO:0016477 cell migration
GO:0060330 regulation of response to interferon-gamma
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002589 Macro domain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
PFAM PF01661
PF00644
PRINTS
PIRSF
SMART SM00506
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IXQ6
PhosphoSite PhosphoSite-Q8IXQ6
TrEMBL Q658Y0
UniProt Splice Variant
Entrez Gene 83666
UniGene Hs.634988
RefSeq NP_113646
HUGO HGNC:24118
OMIM 612065
CCDS CCDS3014
HPRD 10686
IMGT
EMBL AC092908 AC096861 AF307338 AF307339 AK292959 AK313494 AL713679 AL832929 BC017463 BC039580
GenPept AAH39580 AAK07558 AAK07559 BAF85648 BAG36276 CAD28483 CAH56290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca