Version 5.4
Homo sapiens Protein: DIRC2
Summary
InnateDB Protein IDBP-52809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIRC2
Protein Name disrupted in renal carcinoma 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261038
InnateDB Gene IDBG-52807 (DIRC2)
Protein Structure
UniProt Annotation
Function Electrogenic metabolite transporter. {ECO:0000269PubMed:21692750}.
Subcellular Localization Lysosome membrane {ECO:0000269PubMed:21692750}; Multi-pass membrane protein {ECO:0000269PubMed:21692750}.
Disease Associations Note=A chromosomal aberration involving DIRC2 has been found in a family with renal carcinoma. Translocation t(2;3)(q35;q21).
Tissue Specificity Ubiquitous. Expressed in proximal tubular cells of the kidney. {ECO:0000269PubMed:11912179}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006810 transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96SL1
PhosphoSite PhosphoSite-Q96SL1
TrEMBL
UniProt Splice Variant
Entrez Gene 84925
UniGene Hs.734034
RefSeq NP_116228
HUGO HGNC:16628
OMIM 602773
CCDS CCDS3018
HPRD 04142
IMGT
EMBL AK027690 AK075158 AK291176 BC039821 CH471052
GenPept AAH39821 BAB55300 BAC11440 BAF83865 EAW79462

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca