InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AFAP1L1

Summary

InnateDB Protein

IDBP-52851.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AFAP1L1

Protein Name

actin filament associated protein 1-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296721

InnateDB Gene

IDBG-52849 (AFAP1L1)

Protein Structure

UniProt Annotation

Function

May be involved in podosome and invadosome formation. {ECO:0000269PubMed:21333378}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21333378}. Cell projection, podosome {ECO:0000269PubMed:21333378}. Cell projection, invadopodium {ECO:0000269PubMed:21333378}. Note=In the cytosol, associated with actin stress fibers.

Disease Associations

Tissue Specificity

Expressed in breast, colon and brain. In all 3 tissues, expressed in the microvasculature (at protein level). In addition, in the breast, found in the contractile myoepithelial cell layer which surrounds the breast ducts (at protein level). In the colon, expressed in the mucous membrane and colonic crypts and in the smooth muscle cell layer which provide movement of the colon (at protein level). In the cerebellum, localized around the Purkinje neurons and the granule cells of the granular layer, but not inside cell bodies (at protein level). Outside of the cerebellar cortex, expressed in glial cells (at protein level). Highly expressed away from the cell bodies within the dentate nucleus (at protein level). {ECO:0000269PubMed:21333378}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.