Version 5.4
Homo sapiens Protein: RCOR2
Summary
InnateDB Protein IDBP-52865.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RCOR2
Protein Name REST corepressor 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000301459
InnateDB Gene IDBG-52863 (RCOR2)
Protein Structure
UniProt Annotation
Function May act as a component of a corepressor complex that represses transcription. {ECO:0000305}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00512, ECO:0000255PROSITE-ProRule:PRU00624}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID
InterPro IPR000949 ELM2 domain
IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
PFAM PF01448
PF00249
PRINTS
PIRSF
SMART SM00717
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IZ40
PhosphoSite PhosphoSite-Q8IZ40
TrEMBL
UniProt Splice Variant
Entrez Gene 283248
UniGene Hs.98788
RefSeq NP_775858
HUGO HGNC:27455
OMIM
CCDS CCDS8052
HPRD 15234
IMGT
EMBL AP003780 BC010608 BC023587
GenPept AAH10608 AAH23587

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca