InnateDB Protein
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IDBP-52871.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GRPEL2
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Protein Name
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GrpE-like 2, mitochondrial (E. coli)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000329558
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InnateDB Gene
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IDBG-52869 (GRPEL2)
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Protein Structure
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Function |
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion matrix {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000740
GrpE nucleotide exchange factor
IPR009012
GrpE nucleotide exchange factor, head
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PFAM |
PF01025
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PRINTS |
PR00773
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TAA5
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PhosphoSite |
PhosphoSite-Q8TAA5
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TrEMBL |
Q8N3S0
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UniProt Splice Variant |
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Entrez Gene |
134266
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UniGene |
Hs.619552
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RefSeq |
NP_689620
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HUGO |
HGNC:21060
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OMIM |
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CCDS |
CCDS4295
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HPRD |
17079
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IMGT |
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EMBL |
AK074293
AL832325
BC036678
BC070090
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GenPept |
AAH36678
AAH70090
BAB85040
CAD38619
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