Version 5.4
Homo sapiens Protein: IL17B
Summary
InnateDB Protein IDBP-52944.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL17B
Protein Name interleukin 17B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261796
InnateDB Gene IDBG-52942 (IL17B)
Protein Structure
UniProt Annotation
Function Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:1900017 positive regulation of cytokine production involved in inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR010345 Interleukin-17 family
IPR020440 Interleukin-17, chordata
IPR029034 Cystine-knot cytokine
PFAM PF06083
PRINTS PR01932
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHF5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27190
UniGene Hs.409558
RefSeq NP_055258
HUGO HGNC:5982
OMIM 604627
CCDS CCDS4297
HPRD 05217
IMGT
EMBL AF110385 AF152098 AF184969 AF212311 AF218727 AF386077 AY358931 BC113925 BC113946
GenPept AAF01318 AAF28104 AAF78775 AAG39637 AAG44136 AAI13926 AAI13947 AAK60336 AAQ89290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca