Version 5.4
Homo sapiens Protein: GAS2L3
Summary
InnateDB Protein IDBP-52955.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAS2L3
Protein Name growth arrest-specific 2 like 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000266754
InnateDB Gene IDBG-52953 (GAS2L3)
Protein Structure
UniProt Annotation
Function Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269PubMed:21561867}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:21561867}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:21561867}. Note=Localizes to microtubule and actin cytoskeletons.
Disease Associations
Tissue Specificity Expressed in the pancreas, heart, liver, placenta, brain, skeletal muscle, kidney and lung. {ECO:0000269PubMed:21561867}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0007050 cell cycle arrest
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
IPR003108 Growth-arrest-specific protein 2 domain
PFAM PF00307
PF02187
PRINTS
PIRSF
SMART SM00033
SM00243
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86XJ1
PhosphoSite PhosphoSite-Q86XJ1
TrEMBL H0YIT6
UniProt Splice Variant
Entrez Gene 283431
UniGene Hs.20575
RefSeq XP_005268861
HUGO HGNC:27475
OMIM
CCDS CCDS9079
HPRD 13568
IMGT
EMBL AC010200 AC010209 AK315189 BC043366 CH471054
GenPept AAH43366 BAG37629 EAW97641 EAW97642 EAW97644

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca