InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CUL4A

Summary

InnateDB Protein

IDBP-52960.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUL4A

Protein Name

cullin 4A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000322132

InnateDB Gene

IDBG-52956 (CUL4A)

Protein Structure

UniProt Annotation

Function

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL. {ECO:0000269PubMed:14578910, ECO:0000269PubMed:14609952, ECO:0000269PubMed:15448697, ECO:0000269PubMed:15548678, ECO:0000269PubMed:16537899, ECO:0000269PubMed:16678110, ECO:0000269PubMed:23478445, ECO:0000269PubMed:24209620}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 327 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	327 [view]
Protein-Protein	327 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006281	DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0097193	intrinsic apoptotic signaling pathway