InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: B9D2

Summary

InnateDB Protein

IDBP-53013.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B9D2

Protein Name

B9 protein domain 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000243578

InnateDB Gene

IDBG-53011 (B9D2)

Protein Structure

UniProt Annotation

Function

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. {ECO:0000269PubMed:21763481}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:19208769}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269PubMed:19208769}. Nucleus {ECO:0000250}.

Disease Associations

Meckel syndrome 10 (MKS10) [MIM:614175]: A disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. {ECO:0000269PubMed:21763481}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043015	gamma-tubulin binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0042384	cilium assembly

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0036038	TCTN-B9D complex
GO:0036064	ciliary basal body

Protein Structure and Domains

PDB ID

InterPro

IPR010796 B9 domain

PFAM

PF07162

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AC011462 BC004157 BC004444 CH471126

GenPept

AAH04157 AAH04444 EAW57034

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca