Version 5.4
Homo sapiens Protein: MACROD1
Summary
InnateDB Protein IDBP-53042.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MACROD1
Protein Name MACRO domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000255681
InnateDB Gene IDBG-53040 (MACROD1)
Protein Structure
UniProt Annotation
Function Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. {ECO:0000269PubMed:17893710, ECO:0000269PubMed:17914104, ECO:0000269PubMed:19022849, ECO:0000269PubMed:19403568, ECO:0000269PubMed:21257746, ECO:0000269PubMed:23474712}.
Subcellular Localization Nucleus {ECO:0000269PubMed:23474712}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.
Disease Associations Note=A chromosomal aberration involving MACROD1 is found in acute leukemia. Translocation t(11;21)(q13;q22) that forms a RUNX1-MACROD1 fusion protein.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019213 deacetylase activity
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0042278 purine nucleoside metabolic process
GO:0051725 protein de-ADP-ribosylation
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR002589 Macro domain
PFAM PF01661
PRINTS
PIRSF
SMART SM00506
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQ69
PhosphoSite PhosphoSite-Q9BQ69
TrEMBL
UniProt Splice Variant
Entrez Gene 28992
UniGene
RefSeq NP_054786
HUGO HGNC:29598
OMIM 610400
CCDS CCDS8056
HPRD 17448
IMGT
EMBL AF202922 BC000270 BC003188 BC007297 BC008316
GenPept AAF15294 AAH00270 AAH03188 AAH07297 AAH08316

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca