Version 5.4
Homo sapiens Protein: ARHGEF37
Summary
InnateDB Protein IDBP-53068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF37
Protein Name Rho guanine nucleotide exchange factor (GEF) 37
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000328083
InnateDB Gene IDBG-53064 (ARHGEF37)
Protein Structure
UniProt Annotation
Function May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR004148 BAR domain
IPR011511 Variant SH3 domain
PFAM PF00621
PF00018
PF14604
PF03114
PF07653
PRINTS PR00452
PIRSF
SMART SM00325
SM00326
SM00721
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1IGU5
PhosphoSite PhosphoSite-NP_001001669
TrEMBL D6RJH4
UniProt Splice Variant
Entrez Gene 389337
UniGene Hs.256206
RefSeq NP_001001669
HUGO HGNC:34430
OMIM
CCDS CCDS43385
HPRD 13454
IMGT
EMBL AB199796 AC021078 AC022100 AC116360 AK123597
GenPept BAC85655 BAF43710

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca