InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLLT3

Summary

InnateDB Protein

IDBP-53079.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLLT3

Protein Name

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

Synonyms

AF9; YEATS3;

Species

Homo sapiens

Ensembl Protein

ENSP00000369695

InnateDB Gene

IDBG-53077 (MLLT3)

Protein Structure

UniProt Annotation

Function

Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. {ECO:0000269PubMed:20159561, ECO:0000269PubMed:20471948}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00376}.

Disease Associations

Note=A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007379	segment specification
GO:0009952	anterior/posterior pattern specification
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway