InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UTP20

Summary

InnateDB Protein

IDBP-53093.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UTP20

Protein Name

UTP20, small subunit (SSU) processome component, homolog (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261637

InnateDB Gene

IDBG-53091 (UTP20)

Protein Structure

UniProt Annotation

Function

Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269PubMed:17498821}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:11790298, ECO:0000269PubMed:12429849, ECO:0000269PubMed:16458307}. Note=Colocalizes with NCL in the nucleolus.

Disease Associations

Tissue Specificity

Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. {ECO:0000269PubMed:9673349}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364	rRNA processing
GO:0008285	negative regulation of cell proliferation

Cellular Component

GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0030686	90S preribosome
GO:0030688	preribosome, small subunit precursor
GO:0032040	small-subunit processome