InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMP1

Summary

InnateDB Protein

IDBP-53127.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMP1

Protein Name

lysosomal-associated membrane protein 1

Synonyms

CD107a; LAMPA; LGP120;

Species

Homo sapiens

Ensembl Protein

ENSP00000333298

InnateDB Gene

IDBG-53125 (LAMP1)

Protein Structure

UniProt Annotation

Function

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	24 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006914	autophagy
GO:0008626	granzyme-mediated apoptotic signaling pathway
GO:0043323	positive regulation of natural killer cell degranulation
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0048102	autophagic cell death
GO:0050821	protein stabilization
GO:0072594	establishment of protein localization to organelle
GO:0090160	Golgi to lysosome transport
GO:1902513	regulation of organelle transport along microtubule

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005773	vacuole
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0031982	vesicle
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0044194	cytolytic granule
GO:0061474	phagolysosome membrane
GO:0070062	extracellular vesicular exosome
GO:0097208	alveolar lamellar body