InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Inpp5e

Summary

InnateDB Protein

IDBP-531508.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Inpp5e

Protein Name

inositol polyphosphate-5-phosphatase E

Synonyms

1200002L24Rik; 72kDa; mKIAA0123;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119485

InnateDB Gene

IDBG-149167 (Inpp5e)

Protein Structure

UniProt Annotation

Function

Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates. {ECO:0000269PubMed:10806194}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein associated with Golgi stacks.

Disease Associations

Tissue Specificity

Highly expressed in testis, in pachytene and diplotene spermatocytes, but not in more mature elongating spermatids. Detected in neurons throughout the brain. {ECO:0000269PubMed:10806194}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

Biological Process

GO:0046488	phosphatidylinositol metabolic process
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005856	cytoskeleton
GO:0005930	axoneme
GO:0032580	Golgi cisterna membrane

Protein Structure and Domains

PDB ID

MGI:1927753

InterPro

IPR000300 Inositol polyphosphate-related phosphatase
IPR005135 Endonuclease/exonuclease/phosphatase

PFAM

PF03372
PF14529

PRINTS

PIRSF

SMART

SM00128

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JII1

PhosphoSite

PhosphoSite-Q9JII1

TrEMBL

UniProt Splice Variant

Entrez Gene

64436

UniGene

Mm.487781

RefSeq

NP_149125

MGI ID

MGI Symbol

Inpp5e

OMIM

CCDS

CCDS15805

HPRD

IMGT

EMBL

AF226683 AK080075 AK154097 AK170786 BC052717 BC080295

GenPept

AAF86957 AAH52717 AAH80295 BAC37823 BAE32374 BAE42028