InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srsf10

Summary

InnateDB Protein

IDBP-531545.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srsf10

Protein Name

serine/arginine-rich splicing factor 10

Synonyms

Fusip1; FUSIP2; Nssr; NSSR1; NSSR2; Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114564

InnateDB Gene

IDBG-197268 (Srsf10)

Protein Structure

UniProt Annotation

Function

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock (By similarity). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. {ECO:0000250, ECO:0000269PubMed:10583508}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:10583508}.

Disease Associations

Tissue Specificity

Widely expressed, with high levels in brain and testis. {ECO:0000269PubMed:10583508}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0006355	regulation of transcription, DNA-templated
GO:0006376	mRNA splice site selection
GO:0006406	mRNA export from nucleus
GO:0016482	cytoplasmic transport
GO:0048025	negative regulation of mRNA splicing, via spliceosome