Version 5.4
Mus musculus Protein: Ilk
Summary
InnateDB Protein IDBP-531763.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ilk
Protein Name integrin linked kinase
Synonyms AA511515; ESTM24;
Species Mus musculus
Ensembl Protein ENSMUSP00000123443
InnateDB Gene IDBG-204955 (Ilk)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 91 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0004871 signal transducer activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
Biological Process
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001954 positive regulation of cell-matrix adhesion
GO:0006469 negative regulation of protein kinase activity
GO:0007050 cell cycle arrest
GO:0007229 integrin-mediated signaling pathway
GO:0007569 cell aging
GO:0008284 positive regulation of cell proliferation
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010761 fibroblast migration
GO:0014044 Schwann cell development
GO:0014912 negative regulation of smooth muscle cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0021675 nerve development
GO:0022011 myelination in peripheral nervous system
GO:0030030 cell projection organization
GO:0030335 positive regulation of cell migration
GO:0032288 myelin assembly
GO:0032956 regulation of actin cytoskeleton organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0043206 extracellular fibril organization
GO:0043406 positive regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045663 positive regulation of myoblast differentiation
GO:0045773 positive regulation of axon extension
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048812 neuron projection morphogenesis
GO:0050775 positive regulation of dendrite morphogenesis
GO:0051291 protein heterooligomerization
GO:0051897 positive regulation of protein kinase B signaling
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2000178 negative regulation of neural precursor cell proliferation
Cellular Component
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0043025 neuronal cell body
GO:0043034 costamere
GO:0043195 terminal bouton
GO:0043198 dendritic shaft
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:1195267
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YZA5
UniProt Splice Variant
Entrez Gene 16202
UniGene Mm.274846
RefSeq
MGI ID
MGI Symbol Ilk
OMIM
CCDS
HPRD
IMGT
EMBL AC121823
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca