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InnateDB Protein
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IDBP-531799.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Irak2
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Protein Name
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interleukin-1 receptor-associated kinase 2
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Synonyms
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6330415L08Rik; AI649099; IRAK-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000117755
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InnateDB Gene
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IDBG-178161 (Irak2)
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Protein Structure
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| Function |
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
15
[view]
|
| Protein-Protein |
13
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
1
[view]
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
53 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0004672
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protein kinase activity
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GO:0016772
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transferase activity, transferring phosphorus-containing groups
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GO:0042803
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protein homodimerization activity
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GO:0046982
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protein heterodimerization activity
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| Biological Process |
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GO:0001959
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regulation of cytokine-mediated signaling pathway
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GO:0006468
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protein phosphorylation
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GO:0031663
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lipopolysaccharide-mediated signaling pathway
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GO:0032088
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negative regulation of NF-kappaB transcription factor activity
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GO:0042981
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regulation of apoptotic process
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GO:0043433
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negative regulation of sequence-specific DNA binding transcription factor activity
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GO:0045087
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innate immune response (InnateDB)
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GO:0051092
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positive regulation of NF-kappaB transcription factor activity
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GO:0070498
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interleukin-1-mediated signaling pathway
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| Cellular Component |
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| PDB ID |
MGI:2429603
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| InterPro |
IPR011009
Protein kinase-like domain
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
D3Z364
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| UniProt Splice Variant |
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| Entrez Gene |
108960
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| UniGene |
Mm.152142
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Irak2
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AC153987
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| GenPept |
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Version 5.4