Mus musculus Protein: Sp100 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Protein | IDBP-532078.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | Sp100 | ||||||||||||||||
Protein Name | nuclear antigen Sp100 | ||||||||||||||||
Synonyms | A430075G10Rik; | ||||||||||||||||
Species | Mus musculus | ||||||||||||||||
Ensembl Protein | ENSMUSP00000116942 | ||||||||||||||||
InnateDB Gene | IDBG-175861 (Sp100) | ||||||||||||||||
Protein Structure | |||||||||||||||||
UniProt Annotation | |||||||||||||||||
Function | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53- mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. May also play a role in infection by viruses through mechanisms that may involve chromatin and/or transcriptional regulation (By similarity). {ECO:0000250}. | ||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000255PROSITE- ProRule:PRU00185, ECO:0000255PROSITE-ProRule:PRU00747}. Nucleus, PML body {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Accumulates in the cytoplasm upon FAS activation. {ECO:0000250}. | ||||||||||||||||
Disease Associations | |||||||||||||||||
Tissue Specificity | |||||||||||||||||
Comments | |||||||||||||||||
Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||
PDB ID | MGI:109561 | ||||||||||||||||
InterPro |
IPR000770
SAND domain IPR004865 Sp100 IPR010919 SAND domain-like |
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PFAM |
PF01342
PF03172 |
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PRINTS | |||||||||||||||||
PIRSF | |||||||||||||||||
SMART |
SM00258
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TIGRFAMs | |||||||||||||||||
Post-translational Modifications | |||||||||||||||||
Modification | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | O35892 | ||||||||||||||||
PhosphoSite | PhosphoSite-O35892 | ||||||||||||||||
TrEMBL | Q6NTA3 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 20684 | ||||||||||||||||
UniGene | Mm.486514 | ||||||||||||||||
RefSeq | XP_006529345 | ||||||||||||||||
MGI ID | |||||||||||||||||
MGI Symbol | Sp100 | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | AC147806 AC161342 AF038850 AF040241 AF040242 BC069183 U83630 U83636 | ||||||||||||||||
GenPept | AAC40172 AAC40174 AAC53512 AAC53513 AAH69183 | ||||||||||||||||