Version 5.4
Mus musculus Protein: Lck
Summary
InnateDB Protein IDBP-532109.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lck
Protein Name lymphocyte protein tyrosine kinase
Synonyms Hck-3; Lsk; Lskt; p56; p56Lck;
Species Mus musculus
Ensembl Protein ENSMUSP00000119263
InnateDB Gene IDBG-191117 (Lck)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 103 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003823 antigen binding
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0032403 protein complex binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0042802 identical protein binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0051117 ATPase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0007568 aging
GO:0009612 response to mechanical stimulus
GO:0010043 response to zinc ion
GO:0010628 positive regulation of gene expression
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042542 response to hydrogen peroxide
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0046777 protein autophosphorylation
GO:0050853 B cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0070474 positive regulation of uterine smooth muscle contraction
Cellular Component
GO:0001772 immunological synapse
GO:0005911 cell-cell junction
GO:0030139 endocytic vesicle
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID MGI:96756
InterPro IPR001452 SH3 domain
PFAM PF00018
PF14604
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B2KG65
UniProt Splice Variant
Entrez Gene 16818
UniGene Mm.403496
RefSeq
MGI ID
MGI Symbol Lck
OMIM
CCDS
HPRD
IMGT
EMBL AL606921 AL671759
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca