Version 5.4
Mus musculus Protein: Cbs
Summary
InnateDB Protein IDBP-532208.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cbs
Protein Name cystathionine beta-synthase
Synonyms AI047524; AI303044; HIP4;
Species Mus musculus
Ensembl Protein ENSMUSP00000118785
InnateDB Gene IDBG-164615 (Cbs)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004122 cystathionine beta-synthase activity
GO:0020037 heme binding
GO:0030170 pyridoxal phosphate binding
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
GO:0072341 modified amino acid binding
Biological Process
GO:0001958 endochondral ossification
GO:0001974 blood vessel remodeling
GO:0006535 cysteine biosynthetic process from serine
GO:0006565 L-serine catabolic process
GO:0006801 superoxide metabolic process
GO:0019344 cysteine biosynthetic process
GO:0019346 transsulfuration
GO:0019448 L-cysteine catabolic process
GO:0021587 cerebellum morphogenesis
GO:0030823 regulation of cGMP metabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043418 homocysteine catabolic process
GO:0043506 regulation of JUN kinase activity
GO:0050667 homocysteine metabolic process
GO:0050880 regulation of blood vessel size
GO:0051593 response to folic acid
GO:0060135 maternal process involved in female pregnancy
GO:0060351 cartilage development involved in endochondral bone morphogenesis
GO:0070814 hydrogen sulfide biosynthetic process
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005730 nucleolus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:88285
InterPro IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily
PFAM PF00291
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z4K2
UniProt Splice Variant
Entrez Gene 12411
UniGene Mm.206417
RefSeq
MGI ID
MGI Symbol Cbs
OMIM
CCDS
HPRD
IMGT
EMBL AC090881 AC166575
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca