Version 5.4
Mus musculus Protein: Nr2f1
Summary
InnateDB Protein IDBP-532225.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr2f1
Protein Name nuclear receptor subfamily 2, group F, member 1
Synonyms COUP-TF1; COUP-TFI; COUPTFA; EAR3; Erbal3; SVP44; Tcfcoup1;
Species Mus musculus
Ensembl Protein ENSMUSP00000118161
InnateDB Gene IDBG-169423 (Nr2f1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0044323 retinoic acid-responsive element binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001764 neuron migration
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010977 negative regulation of neuron projection development
GO:0021796 cerebral cortex regionalization
GO:0030522 intracellular receptor signaling pathway
GO:0030900 forebrain development
GO:0043401 steroid hormone mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1352451
InterPro IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR008946 Nuclear hormone receptor, ligand-binding
PFAM PF00104
PRINTS PR00545
PR00398
PR01282
PIRSF
SMART SM00430
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3UF74
UniProt Splice Variant
Entrez Gene 13865
UniGene Mm.472293
RefSeq
MGI ID
MGI Symbol Nr2f1
OMIM
CCDS
HPRD
IMGT
EMBL AK148880 CT025642
GenPept BAE28687

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca