InnateDB Protein
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IDBP-532247.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Enpp4
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Protein Name
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ectonucleotide pyrophosphatase/phosphodiesterase 4
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000114429
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InnateDB Gene
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IDBG-184832 (Enpp4)
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Protein Structure
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Function |
Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2682634
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InterPro |
IPR000917
Sulfatase
IPR002591
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR017850
Alkaline-phosphatase-like, core domain
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PFAM |
PF00884
PF01663
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BTJ4
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PhosphoSite |
PhosphoSite-Q8BTJ4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
224794
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UniGene |
Mm.410095
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RefSeq |
XP_006524193
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MGI ID |
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MGI Symbol |
Enpp4
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OMIM |
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CCDS |
CCDS28803
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HPRD |
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IMGT |
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EMBL |
AK090098
AK157622
AK173048
BC027749
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GenPept |
AAH27749
BAC41090
BAD32326
BAE34135
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