Version 5.4
Homo sapiens Protein: HMGXB4
Summary
InnateDB Protein IDBP-5323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGXB4
Protein Name HMG box domain containing 4
Synonyms HMG2L1; HMGBCG; THC211630;
Species Homo sapiens
Ensembl Protein ENSP00000216106
InnateDB Gene IDBG-5321 (HMGXB4)
Protein Structure
UniProt Annotation
Function Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0008333 endosome to lysosome transport
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
Cellular Component
GO:0016589 NURF complex
Protein Structure and Domains
PDB ID
InterPro IPR009071 High mobility group box domain
PFAM PF00505
PF09011
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UGU5
PhosphoSite PhosphoSite-Q9UGU5
TrEMBL Q7Z641
UniProt Splice Variant
Entrez Gene 10042
UniGene Hs.611948
RefSeq NP_001003681
HUGO HGNC:5003
OMIM 604702
CCDS CCDS33641
HPRD 05267
IMGT
EMBL AJ010069 AJ010070 AL008635 AL079310 BC052624 CR456504
GenPept AAH52624 CAA08991 CAA08992 CAB45240 CAG30390 CAI21632

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca