InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nudt7

Summary

InnateDB Protein

IDBP-532339.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nudt7

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 7

Synonyms

1300007B24Rik; 2210404C19Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116868

InnateDB Gene

IDBG-194363 (Nudt7)

Protein Structure

UniProt Annotation

Function

Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'- phosphopantetheine. Has no activity toward NDP-sugars, CDP- alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269PubMed:11415433}.

Subcellular Localization

Peroxisome {ECO:0000269PubMed:11415433}.

Disease Associations

Tissue Specificity

Highly expressed in liver. Expressed at intermediate level in lung and kidney and at low level in brain and heart. {ECO:0000269PubMed:11415433}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003986	acetyl-CoA hydrolase activity
GO:0005102	receptor binding
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding
GO:0030515	snoRNA binding

Biological Process

GO:0009132	nucleoside diphosphate metabolic process
GO:0015938	coenzyme A catabolic process
GO:0046356	acetyl-CoA catabolic process
GO:0050873	brown fat cell differentiation

Cellular Component

GO:0005777

peroxisome

Protein Structure and Domains

PDB ID

MGI:1914778

InterPro

IPR000086 NUDIX hydrolase domain
IPR015797 NUDIX hydrolase domain-like

PFAM

PF00293

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99P30

PhosphoSite

PhosphoSite-Q99P30

TrEMBL

UniProt Splice Variant

Entrez Gene

67528

UniGene

Mm.27889

RefSeq

NP_001277111

MGI ID

MGI Symbol

Nudt7

OMIM

CCDS

HPRD

IMGT

EMBL

AF338424 AK004924 AK011172 AK088191 BC033046 BC069843

GenPept

AAH33046 AAH69843 AAK07483 BAB23675 BAB27446 BAC40199