InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdc23

Summary

InnateDB Protein

IDBP-532340.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc23

Protein Name

CDC23 (cell division cycle 23, yeast, homolog)

Synonyms

6030435O18; D18Ertd243e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122420

InnateDB Gene

IDBG-135646 (Cdc23)

Protein Structure

UniProt Annotation

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0000080	mitotic G1 phase
GO:0007067	mitotic nuclear division
GO:0007080	mitotic metaphase plate congression
GO:0030071	regulation of mitotic metaphase/anaphase transition
GO:0070979	protein K11-linked ubiquitination

Cellular Component

GO:0005622	intracellular
GO:0005680	anaphase-promoting complex

Protein Structure and Domains

PDB ID

MGI:1098815

InterPro

IPR001440 Tetratricopeptide TPR1
IPR007192 Cdc23
IPR008490 Transposase InsH, N-terminal
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF04049
PF05598
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BGZ4