Version 5.4
Mus musculus Protein: Hdac6
Summary
InnateDB Protein IDBP-532355.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hdac6
Protein Name histone deacetylase 6
Synonyms Hd6; Hdac5; mHDA2; Sfc6;
Species Mus musculus
Ensembl Protein ENSMUSP00000121653
InnateDB Gene IDBG-129835 (Hdac6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 143 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 143 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0016787 hydrolase activity
GO:0031593 polyubiquitin binding
GO:0042826 histone deacetylase binding
GO:0042903 tubulin deacetylase activity
GO:0043014 alpha-tubulin binding
GO:0043130 ubiquitin binding
GO:0048156 tau protein binding
GO:0048487 beta-tubulin binding
GO:0051879 Hsp90 protein binding
GO:0070840 dynein complex binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006476 protein deacetylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006515 misfolded or incompletely synthesized protein catabolic process
GO:0007026 negative regulation of microtubule depolymerization
GO:0008152 metabolic process
GO:0009636 response to toxic substance
GO:0009967 positive regulation of signal transduction
GO:0010469 regulation of receptor activity
GO:0010634 positive regulation of epithelial cell migration
GO:0010870 positive regulation of receptor biosynthetic process
GO:0016236 macroautophagy
GO:0016575 histone deacetylation
GO:0032418 lysosome localization
GO:0034983 peptidyl-lysine deacetylation
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043241 protein complex disassembly
GO:0045861 negative regulation of proteolysis
GO:0070201 regulation of establishment of protein localization
GO:0070301 cellular response to hydrogen peroxide
GO:0070842 aggresome assembly
GO:0070845 polyubiquitinated misfolded protein transport
GO:0070846 Hsp90 deacetylation
GO:0070848 response to growth factor
GO:0071218 cellular response to misfolded protein
GO:0090035 positive regulation of chaperone-mediated protein complex assembly
GO:0090042 tubulin deacetylation
GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005881 cytoplasmic microtubule
GO:0005901 caveola
GO:0016235 aggresome
GO:0030286 dynein complex
GO:0031252 cell leading edge
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1333752
InterPro IPR000286 Histone deacetylase superfamily
IPR023801 Histone deacetylase domain
PFAM PF00850
PRINTS PR01270
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3UG37
UniProt Splice Variant
Entrez Gene 15185
UniGene Mm.29854
RefSeq
MGI ID
MGI Symbol Hdac6
OMIM
CCDS
HPRD
IMGT
EMBL AK148144 AL670169
GenPept BAE28372

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca