InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vangl2

Summary

InnateDB Protein

IDBP-532504.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vangl2

Protein Name

vang-like 2 (van gogh, Drosophila)

Synonyms

C530001F03Rik; loop-tail; Lp; Lpp1; Ltap; ska; ska17; stbm; strabismus; Vang1l2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116522

InnateDB Gene

IDBG-204899 (Vangl2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001736	establishment of planar polarity
GO:0001843	neural tube closure
GO:0001942	hair follicle development
GO:0003149	membranous septum morphogenesis
GO:0003150	muscular septum morphogenesis
GO:0003402	planar cell polarity pathway involved in axis elongation
GO:0007266	Rho protein signal transduction
GO:0007275	multicellular organismal development
GO:0009952	anterior/posterior pattern specification
GO:0022007	convergent extension involved in neural plate elongation
GO:0030111	regulation of Wnt signaling pathway
GO:0032835	glomerulus development
GO:0032956	regulation of actin cytoskeleton organization
GO:0035019	somatic stem cell maintenance
GO:0035058	nonmotile primary cilium assembly
GO:0035567	non-canonical Wnt signaling pathway
GO:0036342	post-anal tail morphogenesis
GO:0042060	wound healing
GO:0043507	positive regulation of JUN kinase activity
GO:0045176	apical protein localization
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0048103	somatic stem cell division
GO:0048105	establishment of body hair planar orientation
GO:0048546	digestive tract morphogenesis
GO:0060028	convergent extension involved in axis elongation
GO:0060029	convergent extension involved in organogenesis
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060119	inner ear receptor cell development
GO:0060122	inner ear receptor stereocilium organization
GO:0060488	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060489	planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060490	lateral sprouting involved in lung morphogenesis
GO:0060993	kidney morphogenesis
GO:0061346	planar cell polarity pathway involved in heart morphogenesis
GO:0090102	cochlea development
GO:0090103	cochlea morphogenesis
GO:0090175	regulation of establishment of planar polarity
GO:0090177	establishment of planar polarity involved in neural tube closure
GO:0090179	planar cell polarity pathway involved in neural tube closure

Cellular Component

GO:0001725	stress fiber
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030134	ER to Golgi transport vesicle
GO:0060187	cell pole
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

MGI:2135272

InterPro

IPR009539 Strabismus

PFAM

PF06638

PRINTS

PIRSF

PIRSF007991

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z4X2

UniProt Splice Variant

Entrez Gene

93840

UniGene

Mm.406031

RefSeq

MGI ID

MGI Symbol

Vangl2

OMIM

CCDS

HPRD

IMGT

EMBL

AC158930

GenPept