Version 5.4
Homo sapiens Protein: CEACAM3
Summary
InnateDB Protein IDBP-53255.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEACAM3
Protein Name carcinoembryonic antigen-related cell adhesion molecule 3
Synonyms CD66D; CEA; CGM1; W264; W282;
Species Homo sapiens
Ensembl Protein ENSP00000349971
InnateDB Gene IDBG-53253 (CEACAM3)
Protein Structure
UniProt Annotation
Function Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. {ECO:0000269PubMed:12864848, ECO:0000269PubMed:14707113}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. {ECO:0000269PubMed:11708798}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P40198
PhosphoSite PhosphoSite-P40198
TrEMBL M0QXR5
UniProt Splice Variant
Entrez Gene 1084
UniGene Hs.11
RefSeq NP_001806
HUGO HGNC:1815
OMIM 609142
CCDS CCDS12586
HPRD 16450
IMGT
EMBL AC022516 BC106728 CH471126 D90277 D90278 L00692 L00693
GenPept AAA51969 AAA51970 AAI06729 BAA14321 BAA14322 EAW57062 EAW57063

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca