InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mthfr

Summary

InnateDB Protein

IDBP-532577.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mthfr

Protein Name

5,10-methylenetetrahydrofolate reductase

Synonyms

AI323986;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116239

InnateDB Gene

IDBG-204083 (Mthfr)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004489	methylenetetrahydrofolate reductase (NADPH) activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding
GO:0072341	modified amino acid binding

Biological Process

GO:0001666	response to hypoxia
GO:0006555	methionine metabolic process
GO:0009086	methionine biosynthetic process
GO:0033274	response to vitamin B2
GO:0035999	tetrahydrofolate interconversion
GO:0042493	response to drug
GO:0046500	S-adenosylmethionine metabolic process
GO:0050667	homocysteine metabolic process
GO:0051593	response to folic acid
GO:0055114	oxidation-reduction process
GO:0070555	response to interleukin-1

Cellular Component

GO:0005829	cytosol
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:106639

InterPro

IPR003171 Methylenetetrahydrofolate reductase
IPR029041 FAD-linked oxidoreductase-like

PFAM

PF02219

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q8CJA7

UniProt Splice Variant

Entrez Gene

17769

UniGene

Mm.89959

RefSeq

MGI ID

MGI Symbol

Mthfr

OMIM

CCDS

HPRD

IMGT

EMBL

AF404272 AF404274 AL606929

GenPept

AAN40874 AAN40876