Version 5.4
Mus musculus Protein: Tsc1
Summary
InnateDB Protein IDBP-532719.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tsc1
Protein Name tuberous sclerosis 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000120888
InnateDB Gene IDBG-152579 (Tsc1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0030695 GTPase regulator activity
Biological Process
GO:0001822 kidney development
GO:0001843 neural tube closure
GO:0006813 potassium ion transport
GO:0007399 nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0030030 cell projection organization
GO:0032007 negative regulation of TOR signaling
GO:0032318 regulation of Ras GTPase activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0042552 myelination
GO:0045087 innate immune response (InnateDB)
GO:0045792 negative regulation of cell size
GO:0045859 regulation of protein kinase activity
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050808 synapse organization
GO:0051726 regulation of cell cycle
GO:0055007 cardiac muscle cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0033596 TSC1-TSC2 complex
Protein Structure and Domains
PDB ID MGI:1929183
InterPro IPR007483 Hamartin
IPR016024 Armadillo-type fold
PFAM PF04388
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F2Z3X2
UniProt Splice Variant
Entrez Gene 64930
UniGene Mm.224354
RefSeq
MGI ID
MGI Symbol Tsc1
OMIM
CCDS
HPRD
IMGT
EMBL AL731851
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca