Version 5.4
Mus musculus Protein: Tnfrsf23
Summary
InnateDB Protein IDBP-532731.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfrsf23
Protein Name tumor necrosis factor receptor superfamily, member 23
Synonyms Dctrailr1; mDcTrailr1; mSOB; Tnfrh1; Tnfrsf1al1;
Species Mus musculus
Ensembl Protein ENSMUSP00000116742
InnateDB Gene IDBG-212790 (Tnfrsf23)
Protein Structure
UniProt Annotation
Function Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis through ligand competition. Cannot induce the NF-kappa-B pathway. {ECO:0000269PubMed:12466268}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12466268}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:12466268}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0031362 anchored component of external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:1930269
InterPro IPR001368 TNFR/NGFR cysteine-rich region
PFAM PF00020
PRINTS
PIRSF
SMART SM00208
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ER63
PhosphoSite PhosphoSite-
TrEMBL Q3U3F7
UniProt Splice Variant
Entrez Gene 79201
UniGene Mm.290780
RefSeq NP_077252
MGI ID
MGI Symbol Tnfrsf23
OMIM
CCDS CCDS22044
HPRD
IMGT
EMBL AJ276505 AJ278264 AK154786 AY046550 AY165625 BC106828 BC106829
GenPept AAI06829 AAI06830 AAL05072 AAN87805 BAE32829 CAC16405 CAC27352

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca