InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo9a

Summary

InnateDB Protein

IDBP-532810.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo9a

Protein Name

myosin IXa

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119401

InnateDB Gene

IDBG-173436 (Myo9a)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the eye, lung, liver, brain, heart, kidney, skeletal muscle and spleen. No detection was found in liver. {ECO:0000269PubMed:10409426}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005622	intracellular
GO:0016021	integral component of membrane
GO:0016459	myosin complex

Protein Structure and Domains

PDB ID

MGI:107735

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000159 Ras-association
IPR000198 Rho GTPase-activating protein domain
IPR001609 Myosin head, motor domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029071 Ubiquitin-related domain

PFAM

PF00612
PF00788
PF00620
PF00063
PF00130

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00314
SM00324
SM00242
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt