InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dpf2

Summary

InnateDB Protein

IDBP-532823.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpf2

Protein Name

D4, zinc and double PHD fingers family 2

Synonyms

2210010M07Rik; BAF45D; Req; ubi-d4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120125

InnateDB Gene

IDBG-133574 (Dpf2)

Protein Structure

UniProt Annotation

Function

May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells. {ECO:0000269PubMed:7961935}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

In embryo, highest levels are seen in brain, eyes, thymus and olfactory epithelium in nose, whereas several other tissues, including the musculoskeletal system, show moderate expression. In adult, higher expression in testis, medium in thymus and spleen, lower in certain parts of the brain as the hippocampus. No expression in adult heart, lung, liver, duodenum and kidney. {ECO:0000269PubMed:9680388}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:109529

InterPro

IPR001965 Zinc finger, PHD-type
IPR007087 Zinc finger, C2H2
IPR011011 Zinc finger, FYVE/PHD-type
IPR015880 Zinc finger, C2H2-like
IPR019787 Zinc finger, PHD-finger

PFAM

PF00096
PF00628

PRINTS

PIRSF

SMART

SM00249
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61103