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InnateDB Protein
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IDBP-532866.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Setx
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Protein Name
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senataxin
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000119521
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InnateDB Gene
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IDBG-153367 (Setx)
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Protein Structure
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| Function |
Probable helicase involved in RNA maturation. Required for the 3' transcriptional termination of PER1 and CRY2, plays an important role in the circadian rhythm regulation. Involved in DNA double-strand breaks damage response generated by oxidative stress. {ECO:0000269PubMed:22767893}.
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| Subcellular Localization |
Nucleus, nucleoplasm {ECO:0000269PubMed:16644229}. Nucleus, nucleolus {ECO:0000269PubMed:16644229}. Cytoplasm {ECO:0000269PubMed:16644229}. Note=Most abundant in the nucleus (By similarity). Detected in granules (By similarity). Colocalized in cycling cells with FBL in the nucleolus (By similarity). May be detected in the nucleolus only in cycling cells. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Expressed in cerebellum, hippocampus, olfactory bulb, Bergmann glial fibers, stellate cells and Purkinje cells. Expressed in the epithelial cells of the lens but not in mature lens fiber cells. Expressed in the retina (highly expressed in inner and outer segments of photoreceptors and outer plexiform layer cells but weakly expressed in the inner plexiform and ganglion cell layers). Expressed in the kidney. {ECO:0000269PubMed:16644229}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
4
[view]
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| Protein-Protein |
4
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
5 [view]
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| PDB ID |
MGI:2443480
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-A2AKX3
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
269254
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| UniGene |
Mm.472481
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Setx
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4