InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tgif1

Summary

InnateDB Protein

IDBP-532936.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgif1

Protein Name

TGFB-induced factor homeobox 1

Synonyms

AA959811; AI462167; Tgif;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124168

InnateDB Gene

IDBG-196427 (Tgif1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0070410	co-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001843	neural tube closure
GO:0006355	regulation of transcription, DNA-templated
GO:0007368	determination of left/right symmetry
GO:0008285	negative regulation of cell proliferation
GO:0009953	dorsal/ventral pattern formation
GO:0010470	regulation of gastrulation
GO:0038092	nodal signaling pathway
GO:0042493	response to drug
GO:0045666	positive regulation of neuron differentiation
GO:0048146	positive regulation of fibroblast proliferation
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0060041	retina development in camera-type eye
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1194497

InterPro

IPR001356 Homeobox domain
IPR008422 Homeobox KN domain
IPR009057 Homeodomain-like

PFAM

PF00046
PF05920

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E0CYI0

UniProt Splice Variant

Entrez Gene

21815

UniGene

Mm.472392

RefSeq

MGI ID

MGI Symbol

Tgif1

OMIM

CCDS

HPRD

IMGT

EMBL

AC079441 CT009715

GenPept