InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adra1a

Summary

InnateDB Protein

IDBP-532939.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adra1a

Protein Name

adrenergic receptor, alpha 1a

Synonyms

Adra1c;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125354

InnateDB Gene

IDBG-175481 (Adra1a)

Protein Structure

UniProt Annotation

Function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus membrane {ECO:0000269PubMed:22120526}; Multi-pass membrane protein {ECO:0000269PubMed:22120526}. Cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK- mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004937	alpha1-adrenergic receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001985	negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007512	adult heart development
GO:0007568	aging
GO:0009725	response to hormone
GO:0016049	cell growth
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035265	organ growth
GO:0042493	response to drug
GO:0043410	positive regulation of MAPK cascade
GO:0045760	positive regulation of action potential
GO:0045907	positive regulation of vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction
GO:0060073	micturition
GO:0060402	calcium ion transport into cytosol
GO:0060452	positive regulation of cardiac muscle contraction
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071875	adrenergic receptor signaling pathway
GO:0090037	positive regulation of protein kinase C signaling
GO:0097195	pilomotor reflex

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:104773

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001004 Alpha 1A adrenoceptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)

PFAM

PF00001
PF10320
PF10323

PRINTS

PR00237
PR00557
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97718