Version 5.4
Mus musculus Protein: Bcl2l1
Summary
InnateDB Protein IDBP-532989.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcl2l1
Protein Name BCL2-like 1
Synonyms bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1; Bcl2l; BclX;
Species Mus musculus
Ensembl Protein ENSMUSP00000114911
InnateDB Gene IDBG-209867 (Bcl2l1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 86 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051434 BH3 domain binding
Biological Process
GO:0000910 cytokinesis
GO:0001541 ovarian follicle development
GO:0001701 in utero embryonic development
GO:0001836 release of cytochrome c from mitochondria
GO:0007093 mitotic cell cycle checkpoint
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008584 male gonad development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009314 response to radiation
GO:0009566 fertilization
GO:0009615 response to virus
GO:0019050 suppression by virus of host apoptotic process
GO:0034097 response to cytokine
GO:0040007 growth
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0046898 response to cycloheximide
GO:0046902 regulation of mitochondrial membrane permeability
GO:0051402 neuron apoptotic process
GO:0051881 regulation of mitochondrial membrane potential
GO:0060154 cellular process regulating host cell cycle in response to virus
GO:0070584 mitochondrion morphogenesis
GO:0071230 cellular response to amino acid stimulus
GO:0071312 cellular response to alkaloid
GO:0071480 cellular response to gamma radiation
GO:0071839 apoptotic process in bone marrow
GO:0090005 negative regulation of establishment of protein localization to plasma membrane
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097284 hepatocyte apoptotic process
GO:1900118 negative regulation of execution phase of apoptosis
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000811 negative regulation of anoikis
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005813 centrosome
GO:0005829 cytosol
GO:0031966 mitochondrial membrane
GO:0097136 Bcl-2 family protein complex
Protein Structure and Domains
PDB ID MGI:88139
InterPro IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
IPR013279 Apoptosis regulator, Bcl-X
PFAM PF02180
PRINTS PR01864
PIRSF
SMART SM00265
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2AHX8
UniProt Splice Variant
Entrez Gene 12048
UniGene Mm.238213
RefSeq
MGI ID
MGI Symbol Bcl2l1
OMIM
CCDS
HPRD
IMGT
EMBL AL731857
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca