Version 5.4
Mus musculus Protein: Cycs
Summary
InnateDB Protein IDBP-533011.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cycs
Protein Name cytochrome c, somatic
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000124523
InnateDB Gene IDBG-147074 (Cycs)
Protein Structure
UniProt Annotation
Function Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. {ECO:0000269PubMed:12062423}.Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. {ECO:0000269PubMed:12062423}.
Subcellular Localization Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Disease Associations
Tissue Specificity Found in embryos and in adult liver and heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0009055 electron carrier activity
GO:0020037 heme binding
Biological Process
GO:0006915 apoptotic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005758 mitochondrial intermembrane space
GO:0070469 respiratory chain
Protein Structure and Domains
PDB ID MGI:88578
InterPro IPR002327 Cytochrome c, class IA/ IB
IPR003088 Cytochrome c domain
IPR009056 Cytochrome c-like domain
PFAM PF00034
PF13442
PRINTS PR00604
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62897
PhosphoSite PhosphoSite-P62897
TrEMBL Q56A15
UniProt Splice Variant
Entrez Gene 13063
UniGene Mm.489754
RefSeq NP_031834
MGI ID
MGI Symbol Cycs
OMIM
CCDS CCDS20131
HPRD
IMGT
EMBL AK002732 AK003168 AK005336 AK010651 AK088098 AK143887 BC034363 BC092213 BC094054 CH466597 JF919281 X01756
GenPept AAH34363 AAH92213 AAH94054 AEP27246 BAB22313 BAB22617 BAB23959 BAB27091 BAC40143 BAE25584 CAA25899 EDK98621

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca