InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stat3

Summary

InnateDB Protein

IDBP-533033.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stat3

Protein Name

signal transducer and activator of transcription 3

Synonyms

1110034C02Rik; Aprf; AW109958;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121677

InnateDB Gene

IDBG-211637 (Stat3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 349 experimentally validated interaction(s) in this database.
They are also associated with 196 interaction(s) predicted by orthology.

Experimentally validated
Total	349 [view]
Protein-Protein	235 [view]
Protein-DNA	111 [view]
Protein-RNA	2 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	196 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001659	temperature homeostasis
GO:0001754	eye photoreceptor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0019827	stem cell maintenance
GO:0019953	sexual reproduction
GO:0040014	regulation of multicellular organism growth
GO:0042593	glucose homeostasis
GO:0042755	eating behavior
GO:0045087	innate immune response (InnateDB)
GO:0045820	negative regulation of glycolytic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2001223	negative regulation of neuron migration

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:103038

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q99ML3

UniProt Splice Variant

Entrez Gene

20848

UniGene

Mm.249934

RefSeq

MGI ID

MGI Symbol

Stat3

OMIM

CCDS

HPRD

IMGT

EMBL

AF332507 AL591466

GenPept

AAK17195