InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wars

Summary

InnateDB Protein

IDBP-533034.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wars

Protein Name

tryptophanyl-tRNA synthetase

Synonyms

TrpRS; WRS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124625

InnateDB Gene

IDBG-171081 (Wars)

Protein Structure

UniProt Annotation

Function

T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2- TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Isoform 2 is widely expressed, isoform 1 is found only in embryonic stem cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004830	tryptophan-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001525	angiogenesis
GO:0006418	tRNA aminoacylation for protein translation
GO:0006436	tryptophanyl-tRNA aminoacylation
GO:0045765	regulation of angiogenesis