InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map3k5

Summary

InnateDB Protein

IDBP-533039.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k5

Protein Name

mitogen-activated protein kinase kinase kinase 5

Synonyms

7420452D20Rik; ASK; ASK1; MAPKKK5; Mekk5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122553

InnateDB Gene

IDBG-136255 (Map3k5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004709	MAP kinase kinase kinase activity
GO:0005515	protein binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019903	protein phosphatase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000186	activation of MAPKK activity
GO:0000187	activation of MAPK activity
GO:0002931	response to ischemia
GO:0006468	protein phosphorylation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007254	JNK cascade
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010941	regulation of cell death
GO:0045087	innate immune response (InnateDB)
GO:0070301	cellular response to hydrogen peroxide
GO:0097300	programmed necrotic cell death
GO:1902170	cellular response to reactive nitrogen species

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1346876

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z5H1

UniProt Splice Variant

Entrez Gene

26408

UniGene

Mm.6595

RefSeq

MGI ID

MGI Symbol

Map3k5

OMIM

CCDS

HPRD

IMGT

EMBL

AC158620 AC158621 AC168883 AC171277

GenPept