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InnateDB Protein
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IDBP-533070.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pnrc2
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Protein Name
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proline-rich nuclear receptor coactivator 2
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Synonyms
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0610011E17Rik; D4Bwg0593e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000120788
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InnateDB Gene
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IDBG-197339 (Pnrc2)
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Protein Structure
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| Function |
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Strong expression is detected in lung, spleen, ovary, thymus, and colon. {ECO:0000269PubMed:16181749}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
21 [view]
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Molecular Function |
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| Biological Process |
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GO:0000184
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nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
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| Cellular Component |
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| PDB ID |
MGI:106512
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9CR73
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| TrEMBL |
Z4YMU7
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| UniProt Splice Variant |
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| Entrez Gene |
52830
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| UniGene |
Mm.468111
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Pnrc2
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL672076
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| GenPept |
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Version 5.4