InnateDB Protein
|
IDBP-533118.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Hus1
|
Protein Name
|
Hus1 homolog (S. pombe)
|
Synonyms
|
mHus1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000114339
|
InnateDB Gene
|
IDBG-149401 (Hus1)
|
Protein Structure
|
|
Function |
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In discrete nuclear foci upon DNA damage. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:10395797}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
21 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1277962
|
InterPro |
IPR007150
Checkpoint protein Hus1/Mec3
IPR016580
Cell cycle checkpoint, Hus1
|
PFAM |
PF04005
|
PRINTS |
|
PIRSF |
PIRSF011312
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8BQY8
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
15574
|
UniGene |
Mm.42201
|
RefSeq |
XP_006514594
|
MGI ID |
|
MGI Symbol |
Hus1
|
OMIM |
|
CCDS |
CCDS24429
|
HPRD |
|
IMGT |
|
EMBL |
AF076845
AK046152
AK088403
AK135922
AL669837
BC061249
Y16894
|
GenPept |
AAC95527
AAH61249
BAC32614
BAC40332
BAE22725
CAA76519
CAI24619
|
|
|