InnateDB Protein
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IDBP-533188.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nfya
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Protein Name
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nuclear transcription factor-Y alpha
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Synonyms
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AA407810; Cbf-b; SEZ-10; SEZ10;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000124404
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InnateDB Gene
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IDBG-189923 (Nfya)
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Protein Structure
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Function |
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000269PubMed:24030830}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
43 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0044212
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transcription regulatory region DNA binding
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:2000036
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regulation of stem cell maintenance
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GO:2000648
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positive regulation of stem cell proliferation
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Cellular Component |
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PDB ID |
MGI:97316
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InterPro |
IPR001289
CCAAT-binding transcription factor, subunit B
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PFAM |
PF02045
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PRINTS |
PR00616
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PIRSF |
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SMART |
SM00521
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TIGRFAMs |
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Modification |
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SwissProt |
P23708
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PhosphoSite |
PhosphoSite-P23708
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
18044
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UniGene |
Mm.4929
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RefSeq |
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MGI ID |
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MGI Symbol |
Nfya
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
M86214
M86215
X55315
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GenPept |
AAA39816
AAA39817
CAA39023
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