InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wt1

Summary

InnateDB Protein

IDBP-533204.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wt1

Protein Name

Wilms tumor 1 homolog

Synonyms

D630046I19Rik; Wt-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120702

InnateDB Gene

IDBG-194872 (Wt1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003723	RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001570	vasculogenesis
GO:0001656	metanephros development
GO:0001823	mesonephros development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007281	germ cell development
GO:0007530	sex determination
GO:0008584	male gonad development
GO:0009888	tissue development
GO:0043010	camera-type eye development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071320	cellular response to cAMP
GO:0071371	cellular response to gonadotropin stimulus
GO:1900212	negative regulation of mesenchymal cell apoptotic process involved in metanephros development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:98968

InterPro

IPR000976 Wilm\'s tumour protein, N-terminal
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR017987 Wilm\'s tumour protein

PFAM

PF02165
PF00096

PRINTS

PR00049

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A2A401

UniProt Splice Variant

Entrez Gene

22431

UniGene

Mm.389339

RefSeq

MGI ID

MGI Symbol

Wt1

OMIM

CCDS

HPRD

IMGT

EMBL

AL512584

GenPept