Version 5.4
Mus musculus Protein: Cdk4
Summary
InnateDB Protein IDBP-533212.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdk4
Protein Name cyclin-dependent kinase 4
Synonyms Crk3;
Species Mus musculus
Ensembl Protein ENSMUSP00000122973
InnateDB Gene IDBG-194056 (Cdk4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 126 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 53 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 126 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030332 cyclin binding
GO:0032403 protein complex binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0009636 response to toxic substance
GO:0010288 response to lead ion
GO:0031100 organ regeneration
GO:0033574 response to testosterone
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0045727 positive regulation of translation
GO:0045793 positive regulation of cell size
GO:0048146 positive regulation of fibroblast proliferation
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005923 tight junction
GO:0031965 nuclear membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:88357
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR002575 Aminoglycoside phosphotransferase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF01636
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9JKW8
UniProt Splice Variant
Entrez Gene 12567
UniGene
RefSeq
MGI ID
MGI Symbol Cdk4
OMIM
CCDS
HPRD
IMGT
EMBL AC134329 AF223390
GenPept AAF61074

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca